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・ CXCL6
・ CXCL7
・ CXCL9
・ CXCR3
・ CXCR4
・ CXCR4 antagonist
・ CXCR5
・ CXCR6
・ CXCR7
・ Cxense
・ CXFS
・ CXH
・ CXJ
・ CxK
・ CXL
CXL 1020
・ CXML
・ CXO
・ Cxorf26
・ CXorf36
・ CXorf40A
・ CXorf66
・ CXorf67
・ CXOU J061705.3+222127
・ CXOU J164710.2-455216
・ CXP
・ CXP (connector)
・ CxProcess
・ CXR
・ CXS (disambiguation)


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CXL 1020 : ウィキペディア英語版
CXL 1020

CXL 1020 is an experimental drug that is being investigated as a treatment for acute decompensated heart failure. CXL 1020 functions as a nitroxyl donor; nitroxyl is the reduced, protonated version of nitric oxide. Nitorxyl is capable of enhancing left ventricular contractility without increasing heart rate by modifying normal Ca2+ cycling through the sarcoplasmic reticulum as well as increasing the sensitivity of cardiac myofilaments to Ca2+.
== Acute decompensated heart failure ==
Patients with acute decompensated heart failure have diminished left ventricular systolic and/or diastolic functioning. Impaired ventricular function can be a consequence of decreased sarcoplasmic reticulum Ca2+ cycling and a corresponding decline in cardiomyocyte contraction.〔 Reduced ventricular functioning limits the ability of the ventricles to fill with blood and pump blood to the rest of the body.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「CXL 1020」の詳細全文を読む



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